An ordered assembly of four building blocks (2–5) forms the basis of the synthesis of 1, which contains the core structure of TMC-95A and B—two potent proteasome inhibitors (see scheme; TIPS=triisopropylsilyl, Cbz=benzoxycarbonyl, Boc=tert-butoxycarbonyl).
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Lin et al. (2001) studied this question.
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