Why the study?
Do locally applied prostaglandins prevent thrombus formation in mesenteric arterioles of rats?
Do locally applied prostaglandins prevent thrombus formation in mesenteric arterioles of rats?
Locally applied PGI2 and PGE1 effectively prevent thrombus formation in rat mesenteric arterioles, likely due to their potent inhibition of platelet aggregation rather than vasomotor effects.
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Cautious interpretation required before human use; leaves open selective prostaglandin modulation as an antithrombotic strategy.
SUZUKI, T., the late HAYASHI, A. and TAKANO, S. Effects of Prostaglandins on Thrombus Formation in Mesenteric Arterioles of Rats. Tohoku J. exp. Med., 1982, 137 (1), 65-71-Effects of locally applied prostaglandins on platelet thrombus formation in the mesenteric arterioles of rats were studied in vivo. Prostaglandin (PG) I2 and PGE1, which were reported to be powerful inhibitors of blood platelet aggregation, prevented the thrombus formation, whereas PGE2, which was reported, in low concentrations, to enhance platelet aggregation, showed a tendency to promote the thrombus formation. PGA1, PGA2 or PGF2α had no effect. PGD2 had a very weak inhibitory effect. As prostaglandins tested had no effect on the diameter of mesenteric arterioles, it is assumed that the effectiveness of PGI2 and PGE1 in preventing thrombus formation is due mainly to their powerful inhibiting effects on platelet aggregation.
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Suzuki et al. (1982) studied this question.
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