October 1, 1973Journal of Clinical InvestigationOpen Access

Inhibition of Primary ADP-Induced Platelet Aggregation in Normal Subjects after Administration of Nitrofurantoin (Furadantin)

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Why the study?

Does nitrofurantoin inhibit ADP-induced platelet aggregation in healthy human volunteers?

Population

28 healthy human volunteers for in vivo studies and 12 for in vitro studies

Comparison

Nitrofurantoin vs Baseline or control samples with Tris…

Design

Other

Follow-up

up to 4 hours

Authors

EREnnio C. Rossi NLNathan W. Levin

Discussion

Member takes

Overview

Nitrofurantoin may inhibit ADP-induced platelet aggregation in volunteers; hypothesis-generating for antithrombotic effects, needs confirmation in patients.

Structured PICO

Does nitrofurantoin inhibit ADP-induced platelet aggregation in healthy human volunteers?

Population

28 healthy human volunteers for in vivo studies and 12 for in vitro studies

Intervention

Nitrofurantoin (in vitro: 5-30 μM; in vivo: 200 mg oral single dose or 180 mg intravenous over 2.5 hours)

Comparator

Baseline (pre-administration) or control samples with Tris buffer/saline

Outcome

Velocity of primary ADP-induced platelet aggregationsurrogate

Nitrofurantoin is a potent competitive inhibitor of primary ADP-induced platelet aggregation in vitro and in vivo, with effects proportional to serum concentration.

Cite This Study

Rossi et al. (1973) studied this question.

synapsesocial.com/papers/6a90824d3f736c3f82c7a811 https://doi.org/10.1172/jci107437

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October 1, 1973Journal of Clinical InvestigationOpen Access

Inhibition of Primary ADP-Induced Platelet Aggregation in Normal Subjects after Administration of Nitrofurantoin (Furadantin)

View Full Paper

Ask AI

Bookmark

Why the study?

Does nitrofurantoin inhibit ADP-induced platelet aggregation in healthy human volunteers?

Population

28 healthy human volunteers for in vivo studies and 12 for in vitro studies

Comparison

Nitrofurantoin vs Baseline or control samples with Tris…

Design

Other

Follow-up

up to 4 hours

Authors

EREnnio C. Rossi NLNathan W. Levin

Discussion

Member takes

Overview

Nitrofurantoin may inhibit ADP-induced platelet aggregation in volunteers; hypothesis-generating for antithrombotic effects, needs confirmation in patients.

Structured PICO

Does nitrofurantoin inhibit ADP-induced platelet aggregation in healthy human volunteers?

Population

28 healthy human volunteers for in vivo studies and 12 for in vitro studies

Intervention

Nitrofurantoin (in vitro: 5-30 μM; in vivo: 200 mg oral single dose or 180 mg intravenous over 2.5 hours)

Comparator

Baseline (pre-administration) or control samples with Tris buffer/saline

Outcome

Velocity of primary ADP-induced platelet aggregationsurrogate

Nitrofurantoin is a potent competitive inhibitor of primary ADP-induced platelet aggregation in vitro and in vivo, with effects proportional to serum concentration.

Cite This Study

Rossi et al. (1973) studied this question.

synapsesocial.com/papers/6a90824d3f736c3f82c7a811 https://doi.org/10.1172/jci107437

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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