The release of enzymes from platelets was used as an index of damage to platelet concentrates during their preparation. Enzyme release occurs when aggregated platelets are traumatized. Neither trauma nor aggregation alone produces enzyme release. Enzyme release is increased as the volume of the platelet concentrate is decreased. Aggregated platelets release their enzymes during resuspension whether aggregation is induced by ADP or low temperature. Enzyme release is minimized when platelet concentrates are prepared at 25 C and redispersed 20 to 30 minutes after centrifugation.
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Nabeeh Mourad (1968) studied this question.