Effect of Increased Renal Venous Pressure on Circulatory "Autoregulation" of Isolated Dog Kidneys

The results demonstrate that autoregulation is primarily dependent on the arteriovenous pressure difference and that it is diminished or abolished when this pressure is lower than approximately 90 mm. Hg. it is suggested that in the kidney the arteriovenous pressure gradient is probably close to the true distending pressure (i.e., the transmural pressure) of the intraparenchymal renal arteries and arterioles, It is concluded that renal autoregulation is due to an active response of the muscular coats of the renal arteries and arterioles to changes in transmural pressure.