Fat-deficiency disease of rats. The effect of doses of methyl arachidonate and linoleate on fat metabolism, with a note on the estimation of arachidonic acid

A HIGHLy unsaturated acid containing 20 carbon atoms and four double bonds was isolated by pig's liver as its octabromide and named by him arachidonic acid. Subsequently the same acid was shown by Levene & Rolf [1922] to occur as a constituent of lecithin and kephalin, and since that time it has been shown to be widely distributed in animal tissues. In the ox, it was identified among the fatty acids of the liver, both in the neutral fat and in the phospholipin fraction; it occurs also in the acids from the fat depots and in the phospholipins of the heart, spleen and adrenals [Klenk & v. Schoenebeck, 1932], whilst