Uncovering the complex genetics of human personality: response from authors on the PGMRA Model

Following publication of our two articles [ 1 , 2 ], a critique of the methodology of Phenotype-Genotype Many-to-Many Relations Analysis (PGMRA) [ 1 , 3 , 4 ] questioned the validity of our results from the perspective of polygenic risk scores (PRS) [ 5 ]. We appreciate the importance of these questions, and here provide a concise discussion of the assumptions and mathematical constraints of both approaches. We thank this commentator and others who have discussed our articles with us for their thoughtful questions and critiques.