Answers are grounded in this paper and cite their sources.
A negative-ion mode laser spray interface for use in liquid chromatography/mass spectrometry (LC/MS) has been developed and investigated. The laser spray gave sensitivities that were orders of magnitude better than the negative-ion electrospray for all samples investigated with the exception of sugars. Fragment ions, HSO(-4)and SO(-3), were formed from the laser-sprayed aqueous solution of cholesterol 3-sulfate sodium salt. This suggests that structural information may be obtained directly from the laser-spray mass spectra for thermally labile compounds.
No takes yet. Share an insight, caveat, or question.
Hiraoka et al. (2001) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: