Why the study?
Do captopril and losartan affect erythrocyte membrane Na+/K+-ATPase activity in experimental diabetes mellitus?
Population
Experimental diabetes mellitus model
Design
Preclinical
Authors
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Captopril's ATPase inhibition in diabetic rats should not change prescribing; leaves open human relevance and outcomes.
Do captopril and losartan affect erythrocyte membrane Na+/K+-ATPase activity in experimental diabetes mellitus?
Captopril, but not losartan, inhibits erythrocyte Na+/K+ ATPase activity, suggesting non-sulphydryl ACE inhibitors or ARBs may be preferable in diabetic patients to avoid exacerbating this enzyme's dysfunction.
Temel et al. (2007) studied this question.
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