Submucosal Bladder Neck Injections of Glutaraldehyde Cross-Linked Bovine Collagen for the Treatment of Urinary Incontinence in Patients with the Exstrophy/Epispadias Complex

No AccessJournal of UrologyExternal Genitalia1 Aug 1995Submucosal Bladder Neck Injections of Glutaraldehyde Cross-Linked Bovine Collagen for the Treatment of Urinary Incontinence in Patients with the Exstrophy/Epispadias Complex Jacob Ben-Chaim, Robert D. Jeffs, Dennis S. Peppas, and John P. Gearhart Jacob Ben-ChaimJacob Ben-Chaim More articles by this author , Robert D. JeffsRobert D. Jeffs More articles by this author , Dennis S. PeppasDennis S. Peppas More articles by this author , and John P. GearhartJohn P. Gearhart More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67186-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail During the last 7 years 19 patients underwent 33 transurethral injections of glutaraldehyde cross-linked bovine collagen into the bladder neck for stress incontinence. Of the 15 patients 14 have classic bladder exstrophy, 3 have complete male epispadias and 2 have cloacal exstrophy. The procedure was performed after a Young-Dees-Leadbetter bladder neck reconstruction in 15 patients and before it in 4. Injections were repeated in 10 patients after a mean of 12 months. After a mean followup of 26 months (range 9 to 84) improvement of continence was noted in 10 of 19 patients (53 percent) of whom 4 have significant improvement. Of the 8 patients whose condition failed to improve after collagen injections 6 underwent additional successful surgery to achieve urinary continence. Of the 10 patients who underwent repeated collagen injections 9 (90 percent) had additional improvement. Although there were no complications related to the injected collagen itself, postoperative complications developed in 2 patients. Submucosal injection of collagen to the bladder neck is simple and safe, and has a reasonable success rate. 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Link, Google Scholar Division of Pediatric Urology, Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and University School of Medicine, Baltimore, Maryland.Requests for reprints: Marburg 149, The Johns Hopkins Hospital, 600 North Wolfe St., Baltimore, Maryland 21287-2101.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byWeiss D (2022) The Role of Bladder Neck Injection in the Quest for ContinenceJournal of Urology, VOL. 209, NO. 3, (467-468), Online publication date: 1-Mar-2023.Dyer L, Franco I, Firlit C, Reda E, Levitt S and Palmer L (2007) Endoscopic Injection of Bulking Agents in Children With Incontinence: Dextranomer/Hyaluronic Acid Copolymer Versus PolytetrafluoroethyleneJournal of Urology, VOL. 178, NO. 4S, (1628-1631), Online publication date: 1-Oct-2007.Kitchens D, Minevich E, DeFoor W, Reddy P, Wacksman J, Koyle M and Sheldon C (2018) Incontinence Following Bladder Neck Reconstruction—Is There a Role for Endoscopic Management?Journal of Urology, VOL. 177, NO. 1, (302-306), Online publication date: 1-Jan-2007.HALACHMI S, FARHAT W, METCALFE P, BAGLI D, McLORIE G and KHOURY A (2018) Efficacy of Polydimethylsiloxane Injection to the Bladder Neck and Leaking Diverting Stoma for Urinary ContinenceJournal of Urology, VOL. 171, NO. 3, (1287-1290), Online publication date: 1-Mar-2004.Lottmann H, Margaryan M, Bernuy M, Rouffet M, Bau M, El-Ghoneimi A, Aigrain Y, Stenberg A and Läckgren G (2018) The Effect of Endoscopic Injections of Dextranomer Based Implants on Continence and Bladder Capacity: A Prospective Study of 31 PatientsJournal of Urology, VOL. 168, NO. 4 Part 2, (1863-1867), Online publication date: 1-Oct-2002.GUYS J, FAKHRO A, LOUIS-BORRIONE C, PROST J and HAUTIER A (2018) ENDOSCOPIC TREATMENT OF URINARY INCONTINENCE: LONG-TERM EVALUATION OF THE RESULTSJournal of Urology, VOL. 165, NO. 6 Part 2, (2389-2391), Online publication date: 1-Jun-2001.GUYS J, SIMEONI-ALIAS J, FAKHRO A and DELARUE A (2018) USE OF POLYDIMETHYLSILOXANE FOR ENDOSCOPIC TREATMENT OF NEUROGENIC URINARY INCONTINENCE IN CHILDRENJournal of Urology, VOL. 162, NO. 6, (2133-2135), Online publication date: 1-Dec-1999.MOLLARD P, BASSET T and MURE P (2018) MALE EPISPADIAS: EXPERIENCE WITH 45 CASESJournal of Urology, VOL. 160, NO. 1, (55-59), Online publication date: 1-Jul-1998.Chernoff A, Horowitz M, Combs A, Libretti D, Nitti V and Glassberg K (2018) Periurethral Collagen Injection for the Treatment of Urinary Incontinence in ChildrenJournal of Urology, VOL. 157, NO. 6, (2303-2305), Online publication date: 1-Jun-1997.Perez L, Smith E, Parrott T, Broecker B, Massad C and Woodard J (2018) Submucosal Bladder Neck Injection of Bovine Dermal Collagen for Stress Urinary Incontinence in the Pediatric PopulationJournal of Urology, VOL. 156, NO. 2S, (633-636), Online publication date: 1-Aug-1996. Volume 154Issue 2August 1995Page: 862-864 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.Metrics Author Information Jacob Ben-Chaim More articles by this author Robert D. Jeffs More articles by this author Dennis S. Peppas More articles by this author John P. Gearhart More articles by this author Expand All Advertisement PDF downloadLoading ...