Isovanillin was oxidized with magnesium monoperoxyphthalate to 4‐methoxyresorcinol (2) and the latter was reacted with 3‐oxopropionic acid ethylester prepared in situ to give scopoletin (1). These reactions can be achieved in kg scale in high yields.
No takes yet. Share an insight, caveat, or question.
Hauer et al. (1995) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: