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A promising strategy for the therapy of neurodegenerative diseases consists of the use of chelators. A new cyclic derivative, Cyclo-bi-Phen, was synthesized in one step and found to complex copper and zinc. When used in i.p. injection at 5 mg kg−1 three times per week on double-transgenic mice, this Cyclo-bi-Phen ligand (shown) was able to reduce in vivo Thioflavin-S-stainable amyloid plaques involved in the deleterious effects of the Alzheimer's disease.
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Boldron et al. (2005) studied this question.
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