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January 1, 1977Journal of Analytical Toxicology

High-Pressure Liquid Chromatographic Analysis of Carcinogenic N-Nitroso Derivatives of Piperazine Resulting from Drug-Nitrite Interactions

G. S. K. RAO D.A. McLennon

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Abstract

A high-pressure liquid chromatographic procedure for the simultaneous analysis of N-nitroso and N,N′-dinitroso derivatives of piperazine is described. Its application in assaying these toxic nitrosamines formed under in vitro conditions in human saliva and in vivo conditions in rat stomach is reported.

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RAO et al. (1977) studied this question.

synapsesocial.com/papers/6a908ff01f441c9f75c7aac7 https://doi.org/10.1093/jat/1.1.43

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