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January 1, 2007Cellular & Molecular Biology LettersOpen Access

High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

Yoshifumi Hirokawa Akimitsu Takagi Katsunori Uchida Yuji Kozuka Misao Yoneda Masatoshi Watanabe Taizo Shiraishi

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Abstract

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

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Hirokawa et al. (2007) studied this question.

synapsesocial.com/papers/6a90908bfdb099d0d8dd8e9a https://doi.org/10.2478/s11658-007-0009-y

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