Hypothyroidism after 125I Therapy

Comments1 June 1977Hypothyroidism after 125I TherapyJ. F. MALONE, PH.D., M. J. CULLEN, M.B.J. F. MALONE, PH.D.Search for more papers by this author, M. J. CULLEN, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-6-823 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: McDougall and Greig (1) recently presented their results of125I treatment of Graves' disease. The data are sufficient to allow the incidence of hypothyroidism after this mode of therapy to be examined to see if it conforms to the two-mechanism hypothesis postulated for131I (2). With131I early incidence, 2 years after therapy is linearly related to dose and is thought to be induced directly by radiobiological events. Late incidence, after more than 2 years, is relatively dose independent and hence is thought to be related to some fundamental biological property of the thyroid such as the...References1. MCDOUGALLGREIG IW, 125I Therapy in Graves' disease. Longterm results in 355 Patients. Ann Intern Med 85:720-723, 1976 LinkGoogle Scholar2. MALONECULLEN JM: Hypothyroidism after 131I therapy: a two mechanism hypothesis. Lancet 2:73-75, 1976 CrossrefMedlineGoogle Scholar3. GLENNONGORDONSAWIN JEC: Hypothyroidism after lowdose 131I treatment of hyperthyroidism. Ann Intern Med 76:721-723, 1972 LinkGoogle Scholar4. BECKERMCCONAHEYDOBYNS DWB: The results of radioiodine treatment of hyperthyroidism, in Further Advances in Thyroid Research, edited by FELLINGER K, HOFER R. Vienna, Verlag der Wiener Medizinischen Akademie, 1971, pp. 603-609 Google Scholar5. MALONE J: The radiobiology of the thyroid. Curr Top Radiat Res 10: 263-268, 1975 MedlineGoogle Scholar1. MALONECULLEN JM: Two mechanisms for hypothyroidism after 131I therapy. Lancet 2:73-75, 1976 CrossrefMedlineGoogle Scholar2. DONIACH I: Reconsideration of 125I therapy in Graves' disease. Lancet 1:870, 1975 CrossrefGoogle Scholar3. TURNERBROWNLIEROGERS JBT: Lithium as an adjunct to radioiodine for thyrotoxicosis. Lancet 1:614-615, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDraft Toxicological Profile for IodineConsequences of Iodine Fall Out: Dosimetric and Radiobiological ConsiderationsThe radiobiological response of the thyroid Part I: Sheep thyroid cells in culture as a radiobiological modelThe influence of thyroid geometry on the response of LiF and CaSO4 thermoluminescent discs to 131I and 125I irradiationProceedings of the British Institute of RadiologyThyroid uptake measurements: the influence of gland depth, gland mass and lobe separation 1 June 1977Volume 86, Issue 6Page: 823-824KeywordsHypothyroidismThyroid Issue Published: 1 June 1977 PDF DownloadLoading ...