In this paper the results of the study of 63 GF-resistant mutants derived from sensitive wild strain 155 of Microsporum gypseum are summed up. 1 6 mutants only differed from the wild strain by the character of the colony. The production of spores was preserved in all mutants. 2 All resistant mutants grew on minimal medium in the same way as the wild strain. The origin of resistance to GF is not accompanied by a qualitative change in the requirements for growth substances. 3 The increased resistance to GF is the same in all mutants: their values ED 50 vary between 93–112 μg GF/ml. 4 In the set of independently isolated mutants the resistance to GF is controlled by at least two genes, probably in different linkage groups. By both mutant genes the same resistance level is caused.
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Lenhart et al. (2009) studied this question.
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