An efficient one-pot two-step synthesis of diversified 3-acyl-5-hydroxybenzofurans under microwave irradiation is described. The desired products were synthesized rapidly by adopting the Nenitzescu reaction of enaminones and benzoquinones. This methodology provides us with high proportion of desired products in the crude mixture with short reaction times. These two advantages are especially favorable for generating compound libraries in high-throughput biological screening.
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Cheng et al. (2007) studied this question.