Enantioselective Organocatalytic Conjugate Addition of N Heterocycles to α,β‐Unsaturated Aldehydes

Must love cats.! Chiral amines catalyze the enantioselective addition of N-heterocyclic compounds to α,β-unsaturated compounds in high yields and with enantioselectivities of up to 94 % ee (see scheme; TMS=trimethylsilyl). The intermediates and transition states for the catalytic cycle were identified by performing DFT calculations.