All articles of this category The exceedingly cyctotoxic compound neocarzinostatin chromophore continues to fascinate chemists and biologists. Several groups have set out to synthesize this molecule and/or simplified functional analogues thereof. Pertinent work of our groups is compiled in the following. As an entry to the Z-dienediyne systems we employed Cacchi couplings between the bis(enol triflates) Z - 34 or Z - 35 and terminal alkynes. From there, we synthesized type- 21 and type- 22 dienediynes. They engaged in neocarzinostatin-type cycloaromatizations 23 → 25 and 24 → 26 , respectively. In addition, we prepared dienediynes of general structures 27 or 28 . They were carried on to Saito-Myers cyclizations 29 → 31 and 30 → 32 , respectively. C,C coupling - dienediynes - enediyne antibiotics - enol triflate - neocarzinostatin
No takes yet. Share an insight, caveat, or question.
Brückner et al. (1999) studied this question.