Answers are grounded in this paper and cite their sources.
3-alkoxycarbonyl-1beta-methylcarbapenem could be synthesized by using a palladium-catalyzed C-N bond-forming reaction between vinyl halide and beta-lactam nitrogen. In this reaction, the use of Pd(OAc)(2) and DPEphos gave a good result, and the generation of Pd(0) from Pd(OAc)(2) in the absence of a base is necessary to increase the yield.
No takes yet. Share an insight, caveat, or question.
Kozawa et al. (2003) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: