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September 3, 2008Angewandte Chemie

Total Synthesis of Callystatin A by Titanium‐Mediated Reductive Alkyne–Alkyne Cross‐Coupling

Holly A. Reichard Jude C. Rieger Glenn C. Micalizio

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Abstract

Modulares Vorgehen: Eine kurze Synthese von Callystatin A wurde entwickelt. Die Synthese definiert einen modularen Weg zum hochungesättigten Gerüst der Leptomycine und nutzt eine komplexe titanvermittelte reduktive Alkin-Alkin-Kreuzkupplung als Schlüsselreaktion (siehe Schema; TBS=tert-Butyldimethylsilyl).

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Reichard et al. (2008) studied this question.

synapsesocial.com/papers/6a909827039ece43b30d5c19 https://doi.org/10.1002/ange.200803031

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