N-heterobicyclic scaffolds: Highly efficient palladium-catalyzed cyclizations of oxime esters with cyclic alkenes were used as a general entry to perhydroindole and related scaffolds. The chemistry is reliant upon the use of P(3,5-(CF3)2C6H3)3 for the key C(sp3)N bond-forming process and this facilitates cyclizations with enhanced levels of efficiency across a range of sterically and electronically distinct substrates.
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Faulkner et al. (2012) studied this question.
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