Abstract 4‐(1,3‐Dimethyl‐2,6‐dioxo‐2,6‐dihydropurin‐7‐yl)‐3‐hydroxybutyric acid (4a) and 4‐(6‐amino‐9‐purinyl)‐3‐hydroxybutyric acid (4b) were synthesized through the addition reaction of theophylline or adenine, respectively, to 1‐chloro‐2,3‐epoxypropane followed by cyanization and acidic hydrolysis. Condensation polymerization of 4a was carried out using dicyclohexylcarbodiimide, 2,4,6‐triisopropylbenzenesulfonyl chloride or p‐toluenesulfonyl chloride as dehydrating agents in dimethylformamide or pyridine. The oligoester of 4a was obtained as a white powder with a molecular weight > 700, according to gel filtration measurement.
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Hattori et al. (1977) studied this question.
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