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Two for the price of one: A new tandem reaction involving two consecutive, competitive nucleophilic additions was developed to construct a series of densely functionalized propargylic alcohol derivatives from simple materials without functional protection, in which a variety of electrophiles including cyclopropanone and aromatic aldehydes have been successfully employed. Multiple functionalities in products 1 and 2 make them versatile structural motifs for further elaboration.
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Liu et al. (2008) studied this question.
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