The propargyltitanium reagents derived from 1-alkylpropyne condensed with aldehydes to give α-allenyl alcohol regioselectively, while the allenyltitanium reagents generated from 1-alky1-1-butyne derivatives gave threo-β-acetylenic alcohols with high regio- and stereoselectivities. The course of the reaction was determined by the substitution pattern of starting alkynes. The similar reactions of metallated 1,3-bis(trialkylsilyl)propyne or (trialkylsilyl)acetonitrile with aldehydes were also investigated.
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Furuta et al. (1984) studied this question.
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