A ruthenium-catalyzed direct cross-coupling between alkenes and alkynes via directed C-H bond activation is described. By using N,N-disubstituted aminocarbonyl as a directing group, this oxidant-free and atom-economic protocol resulted in high efficiency and good stereoselectivities, which opens a novel synthetic passway for access to substituted (Z,Z)-butadiene skeletons.
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Meng et al. (2017) studied this question.
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