Australia Antigen: A Genetic Basis for Chronic Liver Disease and Hepatoma?

Editorials1 March 1971Australia Antigen: A Genetic Basis for Chronic Liver Disease and Hepatoma?ALTON I. STUTNICK, M.D., F.A.C.P., W. THOMAS LONDON JR., M.D., F.A.C.P., BARUCH S. BLUMBERG, M.D., PH.D.ALTON I. STUTNICK, M.D., F.A.C.P., W. THOMAS LONDON JR., M.D., F.A.C.P., BARUCH S. BLUMBERG, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-3-442 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of Australia antigen (Au(1)) with chronic hepatitis was first noted in 1966 in a study of patients with Down's syndrome (1). Many of these patients have persistent Australia antigen (as do many members of tropical populations studied previously (2) ). This observation stimulated an investigation of immunologic mechanisms in Down's syndrome patients with and without Au(1). One patient who did not have Australia antigen on previous testing developed it while under our observation. This provided the first evidence that Au(1) could be acquired. The patient went on to develop asymptomatic anicteric hepatitis detected only by biochemical and liver...References1. SUTNICKLONDONGERSTLEY AWB: Anticteric hepatitis associated with Australia antigen: occurrence in patients with Down's syndrome. JAMA 205:670-674, 1968 CrossrefMedlineGoogle Scholar2. BLUMBERGALTERVISNICH BHS: A "new" antigen in leukemia sera. JAMA 191:541-546, 1965 CrossrefMedlineGoogle Scholar3. LONDONSUTNICKBLUMBERG WAB: Australia antigen and acute viral hepatitis. Ann Intern Med 70:55-59, 1969 LinkGoogle Scholar4. SUTNICKLONDONBLUMBERG AWB: Australia antigen and the quest for a hepatitis virus. Amer J Dig Dis 14:189-194, 1969 CrossrefMedlineGoogle Scholar5. BLUMBERGSUTNICKLONDON BAW: Current concepts: Australia antigen and hepatitis. New Eng J Med 283:349-354, 1970 CrossrefMedlineGoogle Scholar6. MACKAYWEIDENHASKER ISJ: Autoimmune hepatitis. Ann NY Acad Sci 124:767-780, 1965 CrossrefMedlineGoogle Scholar7. BLUMBERGLONDONSUTNICK BWA: Australia antigen as a hepatitis virus: variation in host response. Amer J Med 48:1-8, 1970 CrossrefMedlineGoogle Scholar8. WRIGHTMCCOLLUMKLATSKIN RRG: Australia antigen in acute and chronic liver disease. Lancet 2:117-121, 1969 CrossrefMedlineGoogle Scholar9. SUTNICKLONDONBLUMBERG AWB: Australia antigen (a hepatitis-associated antigen) in leukemia. J Nat Cancer Inst 44:1241-1249, 1970 MedlineGoogle Scholar10. BLUMBERGMELARTINLECHAT BLM: Association between lepromatous leprosy and Australia antigen. Lancet 2:173-176, 1967 CrossrefMedlineGoogle Scholar11. LONDONDIFIGLIASUTNICK WMA: An epidemic of hepatitis in a chronic hemodialysis unit. Australia antigen and differences in host response. New Eng J Med 281:571-578, 1969 CrossrefMedlineGoogle Scholar12. BLUMBERGMELARTINGUINTO BLR: Family studies of a human serum isoantigen system (Australia antigen.) Amer J Hum Genet 18:594-608, 1966 MedlineGoogle Scholar13. BLUMBERGFRIEDLAENDERWOODSIDE BJA: Hepatitis and Australia antigen. Autosomal recessive inheritance of susceptibility to infection in humans. Proc Nat Acad Sci USA 62:1108-1115, 1969 CrossrefMedlineGoogle Scholar14. CEPPELLINIBEDARIDOCARBONARA RGA: High frequency and family clustering of Au antigen in some Italian populations, in Proceedings of the International Symposium on Australia Antigen and Viral Hepatitis, Milan, 7 February 1970 Google Scholar15. GOCKEHSUMORGAN DKC: Association between polyarteritis and Australia antigen. Lancet 2:1149-1153, 1970 CrossrefMedlineGoogle Scholar16. TREPOTHIVOLET CJ: Antigène Australien, hépatite a virus et périartérite noueuse. Presse Med 78:1575, 1970 MedlineGoogle Scholar17. DENISONPETERSREYNOLDS GRJ: Familial hepatoma with hepatitis-associated antigen. Ann Intern Med 74:391-394, 1971 LinkGoogle Scholar18. SMITHBLUMBERG JB: Viral hepatitis, postnecrotic cirrhosis and hepatocellular carcinoma (letter). Lancet 2:953, 1969 CrossrefMedlineGoogle Scholar19. BLUMBERGSUTNICKLONDON BAW: Hepatitis and leukemia. Their relation to Australia antigen. Bull NY Acad Med 44:1566-1586. 1968 MedlineGoogle Scholar20. HADZIYANNISMERIKASAFROUDAKIS SGA: Hepatitis-associated antigen in chronic liver disease (letter). Lancet 2:100, 1970 CrossrefGoogle Scholar21. VOGELANTHONYMODY CPN: Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma. Lancet 2:621-624, 1970 CrossrefMedlineGoogle Scholar22. PRINCELEBLANCKROHN ALK: S.H. antigen and chronic liver disease (letter). Lancet 2:717-718, 1970 CrossrefMedlineGoogle Scholar23. OHBAYASHIMAYUMIOKOCHI AMK: Australia antigen in two families with multiple occurrences of cryptogenic cirrhosis of liver. In preparation Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Institute for Cancer Research Fox Chase, Philadelphia, Pa. 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KRAFT, M.D., F.A.C.P.Ricerca sulla contemporanea presenza di α1-fetoproteina e di antigene Australia nelle neoplasie epatiche ed in altre epatopatie. Considerazioni sui possibili rapporti tra infezione epatitica ed epatocarcinomiHepatoma and HAABURTON D. TEPFER, M.D.Occurrence of alpha-fetoprotein in acute viral hepatitisCARCINOGENIC NITROSAMINES IN CANTONESE SALT-DRIED FISHLIVER DISEASE IN CARRIERS OF Au ANTIGENH.A.A. IN PRIMARY LIVER-CELL CARCINOMAHepatocellular carcinoma, positive Australia (hepatitis-associated) antigen and sarcoidosis 1 March 1971Volume 74, Issue 3Page: 442-444KeywordsAntigensChronic hepatitisChronic liver diseaseDown syndromeGenetic diseasesHepatitisHepatocellular carcinomaLiverPopulation statistics ePublished: 1 December 2008 Issue Published: 1 March 1971 PDF downloadLoading ...