Unprecedented Electronic and Steric Effects in Palladium-Catalyzed Asymmetric Allylation: Switching of Enantioselectivity with a Single Chiral Backbone

All articles of this category In the palladium-catalyzed asymmetric substitution reaction between 1,3-diphenylallyl acetate and sodium salt of diethyl malonate, electron-withdrawing and electron-rich P -substituents in a single chiral back-bone give products of opposite stereochemistry. Sterically bulky substituents have the same effect as electron-rich ones. asymmetric allylation - palladium catalyst - steric effects - electronic effects - bidentate phosphinites