Why the study?
Structural information on the PIP2 binding site is lacking because PIP2 could not be resolved in Kir6.2 cryo-EM structures.
Population
Kir6.2 channels
Design
Molecular Dynamics simulation study
Authors
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May inform targeting of KATP gating in metabolic disorders; extends structural models but leaves open clinical translation.
Molecular dynamics simulations provide structural insights into the mechanism of PIP2-induced gating transitions in Kir6.2 channels.
Bründl et al. (2021) studied this question.