For the purpose of improving the fluidity of solids for tabletting, various aqueous slurries containing synthetic aluminium silicate or magnesium carbonate and several kinds of binderes were spray dried using a centrifugal wheel atomizer. Gum arabic, gelatin, poly vinyl alcohol, carboxymethylcellulose, methylcellulose, and poly (vinylpyrolidone) were used as the binders. The finely agglomerated powders (10-80μ) obtained by this process showed free flowing properties and could be easily tablated, as opposed to the original powders. The surface of these products were examined by scanning electron microscopy. Important informations were obtained pertaining to surface topography. The geometric mean diameter (Do) of the agglomerated powder was found to be influenced primarily by the type of binder used and its concentration. Some physicochemical properties of the agglomerated powder, i.e., fluidity and packing, were also examined and the most important factors influencing these properties were found to be particle size and specific surface area.
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Takenaka et al. (1971) studied this question.