Design of Solid Dispersion Particles of Drug with Fine Porous Carriers.

Solid dispersion particles were prepared with indomethacin and fine porous carriers having different pore sizes (Sylysia350, Sylysia740) by use of spray-drying technique. The particles were in the size range of 3-6μm, which is equal to that of the original carrier particles. The indomethacin in solid dispersions was in amorphous state regardless of the type of silica. Specific surface area measurement and DSC analysis of the solid dispersion particles suggested that the difference in pore size of these carrier particles leads to the different drug dispersion of the resultant solid dispersion particles. The drug dissolution properties of solid dispersions were improved compared with crystalline indometacin of γ-form. Solubility of drug formulated into solid dispersions was higher than that of crystalline indomethacin, indicating that the amorphous indomethacin kept its higher energy state in the porous carriers.