Background. The use of wavelet coherence methods enables the identification of frequency-dependent relationships between the phases of the fluctuations found in complex systems such as medical and other biological timeseries. These relationships may illuminate the causal mechanisms that relate the variables under investigation. However, computationally intensive statistical testing is required to ensure that apparent phase relationships are statistically significant, taking into account the tendency for spurious phase relationships to manifest in short stretches of data.
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Sheppard et al. (2017) studied this question.
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