The shut off of cellular protein synthesis following poliovirus infection is not caused by changes to the Poly(A) sequences of cellular mRNA.
Rules out Poly(A) changes as host shutoff mechanism in this model; leaves open alternative pathways and human relevance.
The influence of polio infection on Poly(A) sequences of cellular cytoplasmic RNA was investigated. In the presence of guanidine, cellular protein synthesis was still shut off after poliovirus infection, although there was no viral RNA synthesis. The Poly(A) of these cells was unchanged with respect to quantity, size, and linkage to cellular cytoplasmic RNA. This finding strongly suggests that the shut off of cellular protein synthesis is not caused by a change of the Poly(A) sequences of cellular mRNA.
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Klaus Koschel (1974) studied this question.
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