Highlights the clinical presentation of lymphangiosarcoma as a lethal complication of chronic lymphedema (Stewart-Treves syndrome).
Warrants vigilance for lymphangiosarcoma in chronic lymphedema; extends sparse literature with two new cases and follow-up on 19.
IN 1948, Stewart and Treves1described six cases of a previously unrecognized clinicopathological entity—lymphangiosarcoma in postmastectomy lymphedema. Eighty-eight similar cases2-58from the literature and three unpublished cases (written communications from W. R. Nelson and W. D. McCarthy, on Jan 26, 1966, and April 29, 1966, respectively) have been variously designated angiosarcoma, angioplastic sarcoma, malignant lymphostatic endothelioma, and lymphangioendothelioma and hemangioendothelioma, reflecting the differences in concept regarding the tumor's histogenesis. In addition, 15 cases10,19,30,33,50,59-69of lymphangiosarcoma arising in primary or secondary lymphedematous extremities unassociated with breast carcinoma have been reported. This is a report of two postmastectomy lymphangiosarcomas (Stewart-Treves syndrome) studied at the Henry Ford Hospital since 1960 and a review of the literature, including follow-up information on 19 of the 112 cases. Report of Cases Case 1. —A 68-year-old white woman had lymphedema of the right arm for 18 years following a radical mastectomy and preoperative and
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Charles S. Eby (1967) studied this question.
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