Immune-Mediated Necrotizing Myopathy and Dietary Sources of Statins

Letters19 June 2018Immune-Mediated Necrotizing Myopathy and Dietary Sources of StatinsAriane Barbacki, MD, Sabrina A. Fallavollita, MDCM, Jason Karamchandani, MD, and Marie Hudson, MD, MPHAriane Barbacki, MDSir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada (A.B., S.A.F., M.H.), Sabrina A. Fallavollita, MDCMSir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada (A.B., S.A.F., M.H.), Jason Karamchandani, MDMontreal Neurological Institute and Hospital, Montreal, Quebec, Canada (J.K.), and Marie Hudson, MD, MPHSir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada (A.B., S.A.F., M.H.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0620 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Skeletal muscle diseases caused by autoimmune disorders are classified as idiopathic inflammatory myopathies. Muscle biopsy is used to divide these diseases into polymyositis, dermatomyositis, inclusion body myositis, nonspecific myositis, and immune-mediated necrotizing myopathy. Some patients with immune-mediated necrotizing myopathy have an associated medical condition, such as cancer; a connective tissue disease, such as scleroderma; or a viral infection, such as hepatitis C or HIV. Some patients who have none of these conditions have identifiable autoantibodies that allow them to be classified further. In 1 such group, the antibody is directed against the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This ...References1. Mohassel P, Mammen AL. Statin-associated autoimmune myopathy and anti-HMGCR autoantibodies. Muscle Nerve. 2013;48:477-83. [PMID: 23519993] doi:10.1002/mus.23854 CrossrefMedlineGoogle Scholar2. Pinal-Fernandez I, Mammen AL. Spectrum of immune-mediated necrotizing myopathies and their treatments. Curr Opin Rheumatol. 2016;28:619-24. [PMID: 27607340] doi:10.1097/BOR.0000000000000335 CrossrefMedlineGoogle Scholar3. Lammi C, Zanoni C, Arnoldi A, Vistoli G. Two peptides from soy ß-conglycinin induce a hypocholesterolemic effect in HepG2 cells by a statin-like mechanism: comparative in vitro and in silico modeling studies. J Agric Food Chem. 2015;63:7945-51. [PMID: 26310992] doi:10.1021/acs.jafc.5b03497 CrossrefMedlineGoogle Scholar4. Moongngarm A, Daomukda N, Khumpika S. Chemical compositions, phytochemicals, and antioxidant capacity of rice bran, rice bran layer, and rice germ. APCBEE Procedia. 2012;2 Suppl C 73-9. doi:10.1016/j.apcbee.2012.06.014 CrossrefGoogle Scholar5. Han H, Yan P, Chen L, Luo C, Gao H, Deng Q, et al. Flaxseed oil containing α-linolenic acid ester of plant sterol improved atherosclerosis in ApoE deficient mice. Oxid Med Cell Longev. 2015;2015:958217. [PMID: 26180602] doi:10.1155/2015/958217 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada (A.B., S.A.F., M.H.)Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada (J.K.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0620.This article was published at Annals.org on 20 February 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnvironmental Risks for Inflammatory MyopathiesBecker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing MyopathyStatin-Associated Autoimmune Myopathy and Other Forms of MyositisCase 22-2019: A 65-Year-Old Woman with MyopathyUpdate on muscle disease 19 June 2018Volume 168, Issue 12Page: 893-904KeywordsCholesterolDysphagiaEnzymesIntravenous immunoglobulinLow density lipoproteinMuscle biopsiesMyalgiaMyositisRegenerative medicineStatins ePublished: 20 February 2018 Issue Published: 19 June 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...