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A Nafion film substrate modified with concentrated ammonia was shown to improve the detection of DNA using matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS), especially for DNA strands greater than 200 base pairs. Experimental procedures relating to the detection of DNA by MALDI‐MS using this modified Nafion substrate are described.
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Bai et al. (1995) studied this question.
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