Population
Bovine pulmonary artery endothelial cells and human bronchiolar smooth muscle cells in culture
Comparison
Coculture of BPECs and HBSMCs or transfer of… vs BPECs or HBSMCs cultured alone in serum-free media
Design
Preclinical
Follow-up
72 hours
Authors
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Animal data suggest smooth muscle-derived ET-1 degradation; leaves open its role in vascular tone regulation.
Smooth muscle cells appear to produce a factor that degrades endothelin-1 and big endothelin-1 produced by endothelial cells, highlighting a potential regulatory mechanism in vascular tone.
Cade et al. (1991) studied this question.
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