The number of corpora lutea (CL) was adjusted to 4, 5, 6, 7 or 8 by unilateral ovariectomy at Day 30 to 40 of gestation. The number of CL had no effect on the length of gestation or the level of progesterone and estrogen. There was a significant inverse relationship between litter size and length of gestation. Litter size was correlated positively with the level of estrogen between Day 89 and parturition.
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Martin et al. (1977) studied this question.