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Summary3,4,Dichloroisopropylarterenol (DCI) elevates the FFA level in anesthetized dogs. However, in vitro it does not cause FFA release from adipose tissue. Isoproterenol induces elevations of plasma FFA and glucose which are reduced by DCI (4 mg kg). Glucagon hyperglycemia is also antagonized by DCI. DCI effects in vivo can be overridden by increasing the dose of isoproterenol or glucagon.
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Ashmore et al. (1962) studied this question.
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