Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial

Figures

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  FIGURE 1. The course of cardiac troponin I (nTnI) is during the pre‐ and postoperative periods (2, 12, and 24 h after the procedure). This study included 40 client‐owned dogs that underwent mitral valve repair. The figure contrasts two groups: the control group, which received conventional cardioplegia, and the mDN group, which received a saline‐based modified del Nido cardioplegia solution. A linear mixed‐effects model revealed that cTnI concentrations significantly increased from the baseline values—by 87‐fold at 2 h, 141‐fold at 12 h, and 126‐fold at 24 h postoperatively. In contrast, overall difference between two groups (p = .342) and time‐by‐group interaction were not significant (p = .480, 0.131, and 0.229 at 2, 12, and 24 h postoperatively, respectively), suggesting that the trajectory of cTnI changes over time did not differ between the two cardioplegia protocols (Table 3). The upper and lower boundaries of the box represent the interquartile range, with the top of the box indicating the third quartile (75th percentile) and the bottom indicating the first quartile (25th percentile). The whiskers extend from the box to the highest and lowest values within 1.5 times the…

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  FIGURE 2. Comparison of survival probability after mitral valve repair between the control and modified del Nido (mDN) groups. This study included 40 client‐owned dogs that underwent mitral valve repair. The figure contrasts two groups: the control group, which received conventional cardioplegia, and the mDN group, which received a saline‐based modified del Nido cardioplegia solution. The survival probability at 700 days was 90% (95% confidence interval [CI]: 77.8%–100.0%) in the control group and 90% (95% CI: 77.8%–100.0%) in the mDN group (p = .958). Each step down on the curve represents an all‐cause death, and each tick mark indicates a censored data point.