Nepetaefolins A?J (1?10) and seven known compounds were isolated from the whole plant of Caryopteris nepetaefolia. The absolute configurations of 1?3 were determined from single-crystal X-ray diffraction and spectroscopic data. Compounds 6 and 7, with IC50 values of 6.3?9.0 ?M, showed higher cytotoxicity than paclitaxel in one non-small-cell lung cancer, patient-derived xenograft (PDX) model when tested using PDX models and the adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA).
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Zhang et al. (2017) studied this question.
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