Why the study?
Does one-anastomosis gastric bypass bariatric surgery alter adipose-derived stem cell proliferation and thermogenesis in patients with type 2 diabetes?
Does one-anastomosis gastric bypass bariatric surgery alter adipose-derived stem cell proliferation and thermogenesis in patients with type 2 diabetes?
One-anastomosis gastric bypass enhances the ability of adipose-derived stem cells to differentiate into thermogenic adipocytes, potentially supporting energy expenditure and preventing weight gain.
Answers are grounded in this paper and cite their sources.
May enhance post-bariatric energy expenditure via ADSC thermogenesis; hypothesis-generating and should not yet change practice.
Today, bariatric surgery remains the most effective instrument for weight loss, glycemic control, and type 2 diabetes combat. Bariatric surgery causes mild stimulation of ADSC proliferation and suppresses white adipogenesis. ADSC-derived adipocytes exhibited lipid droplet fragmentation, activation of thermogenesis, and inhibition of lipogenesis. Thus, enhanced ability of ADSC to proliferate and differentiate into thermogenic adipocytes with reduced activity of lipogenesis may support energy expenditure and prevent weight gain after bariatric surgery.
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Stafeev et al. (2025) studied this question.
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