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Introduction Transfusion-associated hemolysis is caused by either immunemediated or non-immune hemolysis. Antibodies and/or complement proteins induce a hemolytic reaction during the acute (acute hemolytic transfusion reaction) [1] and delayed (delayed hemolytic transfusion reaction) phases [2]. Nonimmune mediated causes of transfusion-associated hemolysis include thermal injury [3], osmotic injury [4], mechanical injury [5],
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Fujita et al. (2013) studied this question.
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