The imitation of not only the structure but also the function of the active site of the metalloenzyme phospholipase C seems to have been achieved with complex 1 (Ow = OH2). The two Zn atoms in 1 are bridged by a phenoxy and a carboxylate group. In addition, one Zn atom binds an H2O molecule, which is important for the catalytic process.
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Uhlenbrock et al. (1992) studied this question.
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