An insight into the chemistry of dodecahedranes necessitates access to singly and multiply functionalized derivatives in preparative amounts. The first way failed: several bisseco precursors, including the di- and tetra-substituted derivatives 1 and 2 and the diones 3–5 have been obtained but could not be dehydrogenated to dodecahedrane derivatives.
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Lütz et al. (1989) studied this question.
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