Rapid equilibrium of D‐ and L‐phenylalanines with phenylpyruvic acid (4) was shown to account for their equally efficient incorporation into cytochalasin D (1) by Zygosporium masonii. Transamination of phenylalanines stereospecifically labelled with tritium at C(2) and C(3) proceeded with complete hydrogen loss at the α position and extensive loss at the β position. Considerable suppression of the incorporation of the D‐amino acid by phenylpyruvic acid (4) indicated that the L‐enantiomer is the primary precursor of 1.
No takes yet. Share an insight, caveat, or question.
Vederas et al. (1976) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: