Why the study?
Does the addition of normal plasma and temperature variation affect the migration of human platelets in vitro?
Does the addition of normal plasma and temperature variation affect the migration of human platelets in vitro?
This in vitro study demonstrates a simple procedure for measuring human platelet migration, showing it is temperature-dependent and enhanced by normal plasma.
Optimizing temperature and plasma may enhance in vitro platelet migration assays; leaves open clinical relevance and requires in vivo validation.
Summary A simple procedure is described for measuring migration of human platelets in vitro. Migration increased with temperature reaching maximum values at approximately 30 °C. Addition of normal plasma to the incubation chambers increased migration in all tests and the increase reached twice the control values in 3 of 4 tests. The rate of migration in vitro was relatively rapid for the first 12 hrs. of incubation and then continued at a slower rate for at least an additional 12 hours.
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Paul Nathan (1973) studied this question.
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