Psoriasis physiopathology

Psoriasis is a complex disease presenting as a chronic inflammatory disorder of the skin, mediated by a network of soluble factors and a vast array of cell populations. Although we understand many of the molecular mechanisms and cellular alterations that underlie the disease, we do not yet have a clear view of what sparks off the pathophysiological process leading to plaque development. This review presents current concepts on the pathogenesis of psoriasis and new hypotheses that have emerged from recent research reports.