Research with both humans and several types of mammals has shown PG (prostaglandin)-like substances occurring in ocular tissues. These substances have been shown to be released in substantial amounts in acute anterior uveitis in both rabbits and humans. PGs in general are known to be inflammatory. PGE1 was found to be extremely potent as a vasodilator slightly more so than PGE2. PGF2a is much less vasoactive. Photomicroscopic pictures of eyes following administration of PGs are presented. PGEs tend to increase vascular permeability also. Therefore subsances which inhibit either the synthesis or action of PGs should be valuable in treating acute ocular inflammatory diseases. Polyphloretin phosphate is the most commonly used PG antagonist. Others which function in the same way are aspirin indomethacin and phenylbutazone.
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Whitelocke et al. (1973) studied this question.
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