Fully controlled total synthesis of benanomicin B was achieved by exploiting two key steps: a stereocontrolled ring-opening of a lactone (see scheme, step A), and a semipinacol cyclization of an acetal-aldehyde derivative discriminating the two hydroxy groups of the pseudo-C2-symmetric 1,2-diol moiety (step B).
No takes yet. Share an insight, caveat, or question.
Ohmori et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: